Airway allergy causes alveolar macrophage death, profound alveolar disorganization and surfactant dysfunction.

ABSTRACT: Respiratory disorders caused by allergy have been associated to bronchiolar inflammation leading to life-threatening airway narrowing. However, whether airway allergy causes alveolar dysfunction contributing to the pathology of allergic asthma remains unaddressed. To explore whether airway allergy causes alveolar dysfunction that might contribute to the pathology of allergic asthma, alveolar structural and functional alterations were analyzed during house dust mite (HDM)-induced airway allergy in mice, by flow cytometry, light and electron microscopy, monocyte transfer experiments, assessment of intra-alveolarly-located cells, analysis of alveolar macrophage regeneration in Cx3cr1 ^cre:R26-yfp chimeras, analysis of surfactant-associated proteins, and study of lung s

SUBMITTER: Feo-Lucas L 

PROVIDER: S-EPMC10206250 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature