CCDC134 facilitates T cell activation through the regulation of early T cell receptor signaling.

ABSTRACT: Modulation of surface T cell antigen receptor (TCR) expression is crucial for proper T cell development and maintenance of mature T cell function at steady state and upon stimulation. We previously determined that CCDC134 (coiled-coil domain containing 134), a cytokine-like molecule that served as a potential member of the γc cytokine family, contributes to antitumor responses by augmenting CD8⁺ T cell-mediated immunity. Here we show that T cell-specific deletion of Ccdc134 decreased peripheral mature CD4⁺ and CD8⁺ T cells, which resulted in impaired T cell homeostasis. Moreover, Ccdc134-deficient T cells exhibited an attenuated response to TCR stimulation in vitro, showing lower activation and proliferative capacity. This was further r

SUBMITTER: Zhang T 

PROVIDER: S-EPMC10206301 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature