Integration analysis of tumor metagenome and peripheral immunity data of diffuse large-B cell lymphoma.

ABSTRACT:

Background/purpose

It has been demonstrated that gut microbes are closely associated with the pathogenesis of lymphoma, but the gut microbe landscape and its association with immune cells in diffuse large B-cell lymphoma (DLBCL) remain largely unknown. In this study, we explored the associations between gut microbiota, clinical features and peripheral blood immune cell subtypes in DLBCL.

Method

A total of 87 newly diagnosed DLBCL adults were enrolled in this study. The peripheral blood samples were collected from all patients and then submitted to immune cell subtyping using full-spectral flow cytometry. Metagenomic sequencing was applied to assess the microbiota landscape of 69 of 87 newly diagnosed DLBCL patients. The microbiotas and peripheral blood immune cell subsets wi

SUBMITTER: Zhang Y 

PROVIDER: S-EPMC10206395 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature