Fatty acid amide hydrolase levels in brain linked with threat-related amygdala activation.

ABSTRACT:

Background

Preclinical evidence suggests that increasing levels of the major endocannabinoid anandamide decreases anxiety and fear responses potentially through its effects in the amygdala. Here we used neuroimaging to test the hypothesis that lower fatty acid amide hydrolase (FAAH), the main catabolic enzyme for anandamide, is associated with a blunted amygdala response to threat.

Methods

Twenty-eight healthy participants completed a positron emission tomography (PET) scan with the radiotracer for FAAH, [¹¹C]CURB, as well as a block-design functional magnetic resonance imaging session during which angry and fearful faces meant to activate the amygdala were presented.

Results

[¹¹C]CURB binding in the amygdala as well as in the medial prefrontal c

SUBMITTER: Green DG 

PROVIDER: S-EPMC10206405 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature