Ontology highlight
ABSTRACT:
SUBMITTER: Song J
PROVIDER: S-EPMC10206498 | biostudies-literature | 2023 May
REPOSITORIES: biostudies-literature
Song Jian J Deshpande Tushar T Zhang Xueli X Hannocks Melanie-Jane MJ Lycke Nils N Cardell Susanna L SL Sorokin Lydia L
iScience 20230428 5
Germinal center (GC) formation and antibody production in lymph node follicles require coordinated interactions between B-cells, T-cells and dendritic cells (DCs), orchestrated by the extracellular matrix-rich reticular fiber (RF) network. We describe a unique laminin 523-containing RF network around and between follicles that associates with PDGFrecβ<sup>high</sup>CCL19<sup>low</sup>gp38<sup>low</sup> fibroblastic reticular cells (FRC). In the absence of FRC expression of laminin α5 (<i>pdgfrb- ...[more]