Employing computational tools to design a multi-epitope vaccine targeting human immunodeficiency virus-1 (HIV-1).

ABSTRACT:

Background

Despite being in the 21^st century, the world has still not been able to vanquish the global AIDS epidemic, and the only foreseeable solution seems to be a safe and effective vaccine. Unfortunately, vaccine trials so far have returned unfruitful results, possibly due to their inability to induce effective cellular, humoral and innate immune responses. The current study aims to tackle these limitations and propose the desired vaccine utilizing immunoinformatic approaches that have returned promising results in designing vaccines against various rapidly mutating organisms. For this, all polyprotein and protein sequences of HIV-1 were retrieved from the LANL (Los Alamos National Laboratory) database. The consensus sequence was generated after alignment and used to

SUBMITTER: Sher H 

PROVIDER: S-EPMC10206567 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature