Maternal dendritic cells influence fetal allograft response following murine in-utero hematopoietic stem cell transplantation.

ABSTRACT:

Background

Intrauterine hematopoietic stem cell transplantation (IUT), potentially curative in congenital haematological disease, is often inhibited by deleterious immune responses to donor cells resulting in subtherapeutic donor cell chimerism (DCC). Microchimerism of maternal immune cells (MMc) trafficked into transplanted recipients across the placenta may directly influence donor-specific alloresponsiveness, limiting DCC. We hypothesized that dendritic cells (DC) among trafficked MMc influence the development of tolerogenic or immunogenic responses towards donor cells, and investigated if maternal DC-depletion reduced recipient alloresponsiveness and enhanced DCC.

Methods

Using transgenic CD11c.DTR (C57BL/6) female mice enabled transient maternal DC-depletion with a sing

SUBMITTER: Kandasamy K 

PROVIDER: S-EPMC10206581 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature