Multi-Reconfigurable DNA Origami Nanolattice Driven by the Combination of Orthogonal Signals.

ABSTRACT: The progress of the scaffolded DNA origami technology has enabled the construction of various dynamic nanodevices imitating the shapes and motions of mechanical elements. To further expand the achievable configurational changes, the incorporation of multiple movable joints into a single DNA origami structure and their precise control are desired. Here, we propose a multi-reconfigurable 3 × 3 lattice structure consisting of nine frames with rigid four-helix struts connected with flexible 10-nucleotide joints. The configuration of each frame is determined by the arbitrarily selected orthogonal pair of signal DNAs, resulting in the transformation of the lattice into various shapes. We also demonstrated sequential reconfiguration of the nanolattice and its assemblies from one into another via

SUBMITTER: Watanabe K 

PROVIDER: S-EPMC10206592 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature