Comparison of ventilation defects quantified by Technegas SPECT and hyperpolarized ¹²⁹Xe MRI.

ABSTRACT: Introduction: The ideal contrast agents for ventilation SPECT and MRI are Technegas and ¹²⁹Xe gas, respectively. Despite increasing interest in the clinical utility of ventilation imaging, these modalities have not been directly compared. Therefore, our objective was to compare the ventilation defect percent (VDP) assessed by Technegas SPECT and hyperpolarized ¹²⁹Xe MRI in patients scheduled to undergo lung cancer resection with and without pre-existing obstructive lung disease. Methods: Forty-one adults scheduled to undergo lung cancer resection performed same-day Technegas SPECT, hyperpolarized ¹²⁹Xe MRI, spirometry, and diffusing capacity of the lung for carbon monoxide (DL_CO). Ventilation abnormalities were quantified as the VDP

SUBMITTER: Radadia N 

PROVIDER: S-EPMC10206636 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature