Atherosclerosis Impairs Naive CD4 T-Cell Responses via Disruption of Glycolysis.

ABSTRACT:

Objective

CD4 T cells are important regulators of atherosclerotic progression. The metabolic profile of CD4 T cells controls their signaling and function, but how atherosclerosis affects T-cell metabolism is unknown. Here, we sought to determine the impact of atherosclerosis on CD4 T-cell metabolism and the contribution of such metabolic alterations to atheroprogression.

Approach and results

Using PCR arrays, we profiled the expression of metabolism genes in CD4 T cells from atherosclerotic apolipoprotein-E knockout mice fed a Western diet. These cells exhibited dysregulated expression of genes critically involved in glycolysis and fatty acid degradation, compared with those from animals fed a standard laboratory diet. We examined how T-cell metabolism was changed in either

SUBMITTER: Gaddis DE 

PROVIDER: S-EPMC10206822 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature