Differential effect of anticoagulation according to cognitive function and frailty in older patients with atrial fibrillation.

ABSTRACT:

Background

In older patients with atrial fibrillation (AF), cognitive impairment and frailty are prevalent. It is unknown whether the risk and benefit of anticoagulation differ by cognitive function and frailty.

Methods

A total of 1244 individuals with AF with age ≥65 years and a CHADSVASC score ≥2 were recruited from clinics in Massachusetts and Georgia between 2016 and 18 and followed until 2020. At baseline, frailty status and cognitive function were assessed. Hazard ratios of anticoagulation on physician adjudicated outcomes were adjusted by the propensity for receiving anticoagulation and stratified by cognitive function and frailty status.

Results

The average age was 75.5 (± 7.1) years, 49% were women, and 86% were prescribed oral anticoagulants. At baseline, 52

SUBMITTER: Wang W 

PROVIDER: S-EPMC10207283 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature