The clinical relevance and prediction efficacy from therapy of tumor microenvironment related signature score in colorectal cancer.

ABSTRACT:

Introduction

As the top 3 cancer in terms of incidence and mortality, the first-line treatment for CRC includes FOLFOX, FOLFIRI, Cetuximab or immunotherapy. However, the drug sensitivity of patients to regimens is different. There has been increasing evidence that immune components of TME can affect the sensitivity of patients to drugs. Therefore, it is necessary to define novo molecular subtypes of CRC based on TME immune components, and screen patients who are sensitive to the treatments, to make personalized therapy possible.

Methods

We analyzed the expression profiles and 197 TME-related signatures of 1775 patients using ssGSEA, univariate Cox proportional risk model and LASSO-Cox regression model, and defined a novo molecular subtype (TMERSS) of CRC. Simultaneously, we

SUBMITTER: Jun X 

PROVIDER: S-EPMC10207322 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature