The effect of sleep disorders on dementia risk in patients with traumatic brain injury: A large-scale cohort study.

ABSTRACT:

Introduction

We investigated the association between sleep disorders (SDs) and incident dementia in adults with traumatic brain injury (TBI).

Methods

Adults with a TBI between 2003 and 2013 were followed until incident dementia. Sleep disorders at TBI were predictors in Cox regression models, controlling for other dementia risks.

Results

Over 52 months, 4.6% of the 712,708 adults (59% male, median age 44, <1% with SD) developed dementia. An SD was associated with a 26% and a 23% of increased risk of dementia in male and female participants (hazard ratio [HR] 1.26, 95% confidence interval [CI] 1.11-1.42 and HR 1.23, 95% CI 1.09-1.40, respectively). In male participants, SD was associated with a 93% increased risk of early-onset dementia (HR 1.93, 95% CI 1.29-2.87); thi

SUBMITTER: Mollayeva T 

PROVIDER: S-EPMC10207584 | biostudies-literature | 2023 Apr-Jun

REPOSITORIES: biostudies-literature