SVcnn: an accurate deep learning-based method for detecting structural variation based on long-read data.

ABSTRACT:

Background

Structural variations (SVs) refer to variations in an organism's chromosome structure that exceed a length of 50 base pairs. They play a significant role in genetic diseases and evolutionary mechanisms. While long-read sequencing technology has led to the development of numerous SV caller methods, their performance results have been suboptimal. Researchers have observed that current SV callers often miss true SVs and generate many false SVs, especially in repetitive regions and areas with multi-allelic SVs. These errors are due to the messy alignments of long-read data, which are affected by their high error rate. Therefore, there is a need for a more accurate SV caller method.

Result

We propose a new method-SVcnn, a more accurate deep learning-based method for de

SUBMITTER: Zheng Y 

PROVIDER: S-EPMC10207598 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature