Vascular response patterns to targeted therapies in murine breast cancer models with divergent degrees of malignancy.

ABSTRACT:

Background

Response assessment of targeted cancer therapies is becoming increasingly challenging, as it is not adequately assessable with conventional morphological and volumetric analyses of tumor lesions. The tumor microenvironment is particularly constituted by tumor vasculature which is altered by various targeted therapies. The aim of this study was to noninvasively assess changes in tumor perfusion and vessel permeability after targeted therapy in murine models of breast cancer with divergent degrees of malignancy.

Methods

Low malignant 67NR or highly malignant 4T1 tumor-bearing mice were treated with either the multi-kinase inhibitor sorafenib or immune checkpoint inhibitors (ICI, combination of anti-PD1 and anti-CTLA4). Dynamic contrast-enhanced magnetic resonance im

SUBMITTER: Hoffmann E 

PROVIDER: S-EPMC10207609 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature