Quality of life of pediatric and adult individuals with osteogenesis imperfecta: a meta-analysis.

ABSTRACT:

Background

Osteogenesis imperfecta (OI) is a group of rare inheritable disorders of connective tissue. The cardinal manifestations of OI are low bone mass and reduced bone mineral strength, leading to increased bone fragility and deformity that may lead to significant impairment in daily life. The phenotypic manifestations show a broad range of severity, ranging from mild or moderate to severe and lethal. The here presented meta-analysis aimed to analyze existing findings on quality of life (QoL) in children and adults with OI.

Methods

Nine databases were searched with predefined key words. The selection process was executed by two independent reviewers and was based on predetermined exclusion and inclusion criteria. The quality of each study was assessed using a risk of bia

SUBMITTER: Wehrli S 

PROVIDER: S-EPMC10207627 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature