3D bioprinting patient-derived induced pluripotent stem cell models of Alzheimer's disease using a smart bioink.

ABSTRACT:

Background

Alzheimer's disease (AD), a progressive neurodegenerative disorder, is becoming increasingly prevalent as our population ages. It is characterized by the buildup of amyloid beta plaques and neurofibrillary tangles containing hyperphosphorylated-tau. The current treatments for AD do not prevent the long-term progression of the disease and pre-clinical models often do not accurately represent its complexity. Bioprinting combines cells and biomaterials to create 3D structures that replicate the native tissue environment and can be used as a tool in disease modeling or drug screening.

Methods

This work differentiated both healthy and diseased patient-derived human induced pluripotent stems cells (hiPSCs) into neural progenitor cells (NPCs) that were bioprinted using t

SUBMITTER: Benwood C 

PROVIDER: S-EPMC10207712 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature