Effects of formalin fixation on polarimetric properties of brain tissue: fresh or fixed?

ABSTRACT:

Significance

Imaging Mueller polarimetry (IMP) appears as a promising technique for real-time delineation of healthy and neoplastic tissue during neurosurgery. The training of machine learning algorithms used for the image post-processing requires large data sets typically derived from the measurements of formalin-fixed brain sections. However, the success of the transfer of such algorithms from fixed to fresh brain tissue depends on the degree of alterations of polarimetric properties induced by formalin fixation (FF).

Aim

Comprehensive studies were performed on the FF induced changes in fresh pig brain tissue polarimetric properties.

Approach

Polarimetric properties of pig brain were assessed in 30 coronal thick sections before and after FF using a wide-field IMP sy

SUBMITTER: Gros R 

PROVIDER: S-EPMC10207713 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature