Temporal changes in characteristics and external validity of randomized controlled trials in older people from 2012 to 2019.

ABSTRACT:

Background

Older individuals are often underrepresented in clinical trials. In 2012 only 7% of RCT's specifically studied older people and their geriatric characteristics were poorly reported. The aim of this review was to investigate temporal changes in characteristics and external validity of randomized controlled trials in older people from 2012 to 2019.

Methods

PubMed was searched for randomized clinical trials (RCTs) published in 2019. Firstly, the proportion of RCTs specially designed for older people were determined by the following criteria: a reported mean age of ≥ 70 years or a lower age cutoff of ≥ 55. Secondly, the trials with a majority of older people, defined by a reported mean age of ≥ 60 years, were screened for reporting of geriatric assessments. Both parts

SUBMITTER: van Eijk E 

PROVIDER: S-EPMC10207774 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature