Extracellular vesicle-microRNAs mediated response of bovine ovaries to seasonal environmental changes.

ABSTRACT:

Background

Among the various seasonal environmental changes, elevated ambient temperature during the summer season is a main cause of stress in dairy and beef cows, leading to impaired reproductive function and fertility. Follicular fluid extracellular vesicles (FF-EVs) play an important role in intrafollicular cellular communication by, in part, mediating the deleterious effects of heat stress (HS). Here we aimed to investigate the changes in FF-EV miRNA cargoes in beef cows in response to seasonal changes: summer (SUM) compared to the winter (WIN) season using high throughput sequencing of FF-EV-coupled miRNAs. In addition to their biological relevance, the potential mechanisms involved in the packaging and release of those miRNAs as a response to environmental HS were elucidated

SUBMITTER: Gad A 

PROVIDER: S-EPMC10207814 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature