Metal-free highly chemo-selective bisphosphorylation and deoxyphosphorylation of carboxylic acids.

ABSTRACT: Carboxylic acids are readily available in both the natural and synthetic world. Their direct utilization for preparing organophosphorus compounds would greatly benefit the development of organophosphorus chemistry. In this manuscript, we describe a novel and practical phosphorylating reaction under transition metal-free reaction conditions that can selectively convert carboxylic acids into the P-C-O-P motif-containing compounds through bisphosphorylation, and the benzyl phosphorus compounds through deoxyphosphorylation. This strategy provides a new route for carboxylic acid conversion as the alkyl source, enabling highly efficient and practical synthesis of the corresponding value-added organophosphorus compounds with high chemo-selectivity and wide substrate scope, including the late modi

SUBMITTER: Gan L 

PROVIDER: S-EPMC10207878 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature