Adherence to, and Persistence of, Antidepressant Therapy in Patients with Major Depressive Disorder: Results from a Population-based Study in Italy.

ABSTRACT:

Background

Major depressive disorders represent a significant burden to society, and it is recommended that antidepressant therapy should last at least 6 months. In Italy, antidepressant use in clinical practice was reported to increase by 1.7% in 2020 compared to 2019, but only 40% of new prescriptions are characterized by a treatment duration longer than 3 months.

Objective

The study aims to describe adherence and persistence to therapy in a subset of antidepressants (citalopram, duloxetine, escitalopram, paroxetine, sertraline, venlafaxine) vs. vortioxetine in Italy during a 2-year period from 2017 to 2019.

Methods

A retrospective analysis of the longitudinal patient database reporting data from general practitioners on drug prescriptions in Italy was carried out i

SUBMITTER: Di Nicola M 

PROVIDER: S-EPMC10207922 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature