Gene-based Confirmatory Germline Testing Following Tumor-only Sequencing of Prostate Cancer.

ABSTRACT:

Background

Tumor-only genomic profiling is an important tool in therapeutic management of men with prostate cancer. Since clinically actionable germline variants may be reflected in tumor profiling, it is critical to identify which variants have a higher risk of being germline in origin to better counsel patients and prioritize genetic testing.

Objective

To determine when variants found on tumor-only sequencing of prostate cancers should prompt confirmatory germline testing.

Design, setting, and participants

Men with prostate cancer who underwent both tumor and germline sequencing at Memorial Sloan Kettering Cancer Center from January 1, 2015 to January 31, 2020 were evaluated.

Outcome measurements and statistical analysis

Tumor and germline profiles were analy

SUBMITTER: Truong H 

PROVIDER: S-EPMC10208030 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature