Solute carrier-related signature for assessing prognosis and immunity in patients with clear-cell renal cell carcinoma.

ABSTRACT:

Background

Clear-cell renal cell carcinoma (ccRCC) is the most common malignant kidney cancer. However, the tumor microenvironment and crosstalk involved in metabolic reprogramming in ccRCC are not well-understood.

Methods

We used The Cancer Genome Atlas to obtain ccRCC transcriptome data and clinical information. The E-MTAB-1980 cohort was used for external validation. The GENECARDS database contains the first 100 solute carrier (SLC)-related genes. The predictive value of SLC-related genes for ccRCC prognosis and treatment was assessed using univariate Cox regression analysis. An SLC-related predictive signature was developed through Lasso regression analysis and used to determine the risk profiles of patients with ccRCC. Patients in each cohort were separated into high- a

SUBMITTER: Bao W 

PROVIDER: S-EPMC10208045 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature