Ruthenium-catalysed decarboxylative unsymmetric dual ortho-/meta-C-H bond functionalization of arenecarboxylic acids.

ABSTRACT: Here, we describe a ruthenium-catalysed decarboxylative unsymmetric ortho-C-H azaarylation/meta-C-H alkylation via a traceless directing group relay strategy. The installation of a 2-pyridyl functionality via carboxyl directed ortho-C-H activation is critical to promote decarboxylation and enable meta-C-H bond alkylation to streamline the synthesis of 4-azaaryl-benzo-fused five-membered heterocycles. This protocol is characterized by high regio- and chemoselectivity, broad substrate scopes, and good functional group tolerance under redox-neutral conditions.

SUBMITTER: Li X 

PROVIDER: S-EPMC10208063 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature