Cortical dynein drives centrosome clustering in cells with centrosome amplification.

ABSTRACT: During cell division, the microtubule nucleating and organizing organelle, known as the centrosome, is a critical component of the mitotic spindle. In cells with two centrosomes, each centrosome functions as an anchor point for microtubules, leading to the formation of a bipolar spindle and progression through a bipolar cell division. When extra centrosomes are present, multipolar spindles form and the parent cell may divide into more than two daughter cells. Cells that are born from multipolar divisions are not viable, and hence clustering of extra centrosomes and progression to a bipolar division are critical determinants of viability in cells with extra centrosomes. We combine experimental approaches with computational modeling to define a role for cortical dynein in centrosome clusteri

SUBMITTER: Mercadante DL 

PROVIDER: S-EPMC10208098 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature