DNA methylation and gene expression changes in mouse mammary tissue during successive lactations: part II - the impact of lactation rank.

ABSTRACT: Mastitis is among the main reasons women cease breastfeeding. In farm animals, mastitis results in significant economic losses and the premature culling of some animals. Nevertheless, the effect of inflammation on the mammary gland is not completely understood. This article discusses the changes to DNA methylation in mouse mammary tissue caused by lipopolysaccharide-induced inflammation after in vivo intramammary challenges and the differences in DNA methylation between 1^st and 2^nd lactations. Lactation rank induces 981 differential methylations of cytosines (DMCs) in mammary tissue. Inflammation in 1^st lactation compared to inflammation in 2^nd lactation results in the identification of 964 DMCs. When comparing inflammation in 1^st v

SUBMITTER: Ivanova E 

PROVIDER: S-EPMC10208124 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature