Development and Validation of a Multi-institutional Nomogram of Outcomes for PSMA-PET-Based Salvage Radiotherapy for Recurrent Prostate Cancer.

ABSTRACT:

Importance

Prostate-specific antigen membrane positron-emission tomography (PSMA-PET) is increasingly used to guide salvage radiotherapy (sRT) after radical prostatectomy for patients with recurrent or persistent prostate cancer.

Objective

To develop and validate a nomogram for prediction of freedom from biochemical failure (FFBF) after PSMA-PET-based sRT.

Design, setting, and participants

This retrospective cohort study included 1029 patients with prostate cancer treated between July 1, 2013, and June 30, 2020, at 11 centers from 5 countries. The initial database consisted of 1221 patients. All patients had a PSMA-PET scan prior to sRT. Data were analyzed in November 2022.

Exposures

Patients with a detectable post-radical prostatectomy prostate-specific antige

SUBMITTER: Zamboglou C 

PROVIDER: S-EPMC10208140 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature