Impact of tobacco, alcohol, and marijuana on genome-wide DNA methylation and its relationship with hypertension.

ABSTRACT: Tobacco, alcohol, and marijuana consumption is an important public health problem because of their high use worldwide and their association with the risk of mortality and many health conditions, such as hypertension, which is the commonest risk factor for death throughout the world. A likely pathway of action of substance consumption leading to persistent hypertension is DNA methylation. Here, we evaluated the effects of tobacco, alcohol, and marijuana on DNA methylation in the same cohort (N = 3,424). Three epigenome-wide association studies (EWAS) were assessed in whole blood using the InfiniumHumanMethylationEPIC BeadChip. We also evaluated the mediation of the top CpG sites in the association between substance consumption and hypertension. Our analyses showed 2,569 CpG sites dif

SUBMITTER: Carreras-Gallo N 

PROVIDER: S-EPMC10208152 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature