Identifying the genetic causes of developmental disorders and intellectual disability in Africa: a systematic literature review.

ABSTRACT: Objective: Genetic variants cause a significant portion of developmental disorders and intellectual disabilities (DD/ID), but clinical and genetic heterogeneity makes identification challenging. Compounding the issue is a lack of ethnic diversity in studies into the genetic aetiology of DD/ID, with a dearth of data from Africa. This systematic review aimed to comprehensively describe the current knowledge from the African continent on this topic. Method: Applicable literature published up until July 2021 was retrieved from PubMed, Scopus and Web of Science databases, following PRISMA guidelines, focusing on original research reports on DD/ID where African patients were the focus of the study. The quality of the dataset was assessed using appraisal tools from the Joanna Briggs

SUBMITTER: Baine-Savanhu F 

PROVIDER: S-EPMC10208355 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature