Associative learning contributes to the persistence of fatigue-like behavior in male mice in a model of cancer survivorship.

ABSTRACT: Persistent fatigue is a debilitating side effect that impacts a significant proportion of cancer survivors for which there is not yet an FDA-approved treatment. While certainly a multi-factorial problem, persistent fatigue could be due, in part, to associations learned during treatment. Therefore, we sought to investigate the role of associative learning in the persistence of fatigue using a preclinical model of cancer survivorship. For this purpose, we used a murine model of human papilloma virus-related head and neck cancer paired with a curative regimen of cisplatin-based chemoradiation in male C57BL/6J mice. Fatigue-like behavior was assessed by measuring variations in voluntary wheel running using a longitudinal design. Treatment robustly decreased voluntary wheel running, and this ef

SUBMITTER: Vichaya EG 

PROVIDER: S-EPMC10208403 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature