Dynamics of pulsatile activities of arcuate kisspeptin neurons in aging female mice.

ABSTRACT: Reproductive senescence is broadly observed across mammalian females, including humans, eventually leading to a loss of fertility. The pulsatile secretion of gonadotropin-releasing hormone (GnRH), which is essential for gonad function, is primarily controlled by kisspeptin neurons in the hypothalamic arcuate nucleus (ARC^kiss), the pulse generator of GnRH. The pulsatility of GnRH release, as assessed by the amount of circulating gonadotropin, is markedly reduced in aged animals, suggesting that the malfunctions of ARC^kiss may be responsible for reproductive aging and menopause-related disorders. However, the activity dynamics of ARC^kiss during the natural transition to reproductive senescence remain unclear. Herein, we introduce chronic in vivo Ca²⁺

SUBMITTER: Goto T 

PROVIDER: S-EPMC10208635 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature