Identification of CD8 + T-Cell-Immune Cell Communications in Ileal Crohn's Disease.

ABSTRACT:

Introduction

Crohn's disease (CD) is a major subtype of inflammatory bowel disease (IBD), a spectrum of chronic intestinal disorders caused by dysregulated immune responses to gut microbiota. Although transcriptional and functional changes in a number of immune cell types have been implicated in the pathogenesis of IBD, the cellular interactions and signals that drive these changes have been less well-studied.

Methods

We performed Cellular Indexing of Transcriptomes and Epitopes by sequencing on peripheral blood, colon, and ileal immune cells derived from healthy subjects and patients with CD. We applied a previously published computational approach, NicheNet, to predict immune cell types interacting with CD8 + T-cell subsets, revealing putative ligand-receptor pairs and key

SUBMITTER: Duong HG 

PROVIDER: S-EPMC10208704 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature