Mitochondrial Ribosomal Protein L14 Promotes Cell Growth and Invasion by Modulating Reactive Oxygen Species in Thyroid Cancer.

ABSTRACT:

Objectives

The mitochondrial ribosomal protein L14 (MRPL14) is encoded by a nuclear gene and participates in mitochondrial protein translation. In this study, we aimed to investigate the role of MRPL14 in thyroid cancer.

Methods

We investigated the association between MRPL14 expression and clinicopathological features using The Cancer Genome Atlas (TCGA) and Chungnam National University Hospital (CNUH) databases. Functional studies of MRPL14, including proliferation, migration, invasion, mitochondrial oxidative phosphorylation and reactive oxygen species (ROS) production, were performed in papillary thyroid cancer (PTC) cell lines (B-CPAP and KTC-1).

Results

Based on the TCGA dataset, PTC tissues lost mitochondrial integrity and showed dysregulated expression of overa

SUBMITTER: Kim HJ 

PROVIDER: S-EPMC10208851 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature