Identification and Characterization of mRNA and lncRNA Expression Profiles in Age-Related Hearing Loss.

ABSTRACT:

Objectives

Age-related hearing loss (ARHL), or presbycusis, is caused by disorders of sensory hair cells and auditory neurons. Many studies have suggested that the accumulation of mitochondrial DNA damage, the production of reactive oxygen species, noise, inflammation, and decreased antioxidant function are associated with subsequent cochlear senescence in response to aging stress. Long non-coding RNA (lncRNA) has been reported to play important roles in various diseases. However, the function of lncRNA in ARHL remains unclear. In this study, we analyzed the common expression profiles of messenger RNA (mRNA) and lncRNA through ARHL-related RNA-sequencing datasets.

Methods

We selected and downloaded three different sets of RNA-sequencing data for ARHL. We performed differenti

SUBMITTER: Kim J 

PROVIDER: S-EPMC10208853 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature