The gut microbiome modulates the transformation of microglial subtypes.
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ABSTRACT:
SUBMITTER: Huang Y
PROVIDER: S-EPMC10208978 | biostudies-literature | 2023 Apr
REPOSITORIES: biostudies-literature
Publications
The gut microbiome modulates the transformation of microglial subtypes.
Huang Yu Y Wu Jing J Zhang Hanping H Li Yifan Y Wen Lu L Tan Xunmin X Cheng Ke K Liu Yiyun Y Pu Juncai J Liu Lanxiang L Wang Haiyang H Li Wenxia W Perry Seth W SW Wong Ma-Li ML Licinio Julio J Zheng Peng P Xie Peng P
Molecular psychiatry 20230313 4
Clinical and animal studies have shown that gut microbiome disturbances can affect neural function and behaviors via the microbiota-gut-brain axis, and may be implicated in the pathogenesis of several brain diseases. However, exactly how the gut microbiome modulates nervous system activity remains obscure. Here, using a single-cell nucleus sequencing approach, we sought to characterize the cell type-specific transcriptomic changes in the prefrontal cortex and hippocampus derived from germ-free ( ...[more]
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