AXL Expression on Homeostatic Resident Liver Macrophages Is Reduced in Cirrhosis Following GAS6 Production by Hepatic Stellate Cells.

ABSTRACT:

Background & aims

AXL and MERTK expression on circulating monocytes modulated immune responses in patients with cirrhosis (CD14⁺HLA-DR⁺AXL⁺) and acute-on-chronic liver failure (CD14⁺MERTK⁺). AXL expression involved enhanced efferocytosis, sustained phagocytosis, but reduced tumor necrosis factor-α/interleukin-6 production and T-cell activation, suggesting a homeostatic function. Axl was expressed on murine airway in tissues contacting the external environment, but not interstitial lung- and tissue-resident synovial lining macrophages. Here, we assessed AXL expression on tissue macrophages in patients with cirrhosis.

Methods

Using multiplexed immunofluorescence we compared AXL expression in liver biopsies in cirrhosis (n 

SUBMITTER: Pop OT 

PROVIDER: S-EPMC10209017 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature