Activation of TrkB in Parvalbumin interneurons is required for the promotion of reversal learning in spatial and fear memory by antidepressants.

ABSTRACT: Critical period-like plasticity (iPlasticity) can be reinstated in the adult brain by several interventions, including drugs and optogenetic modifications. We have demonstrated that a combination of iPlasticity with optimal training improves behaviors related to neuropsychiatric disorders. In this context, the activation of TrkB, a receptor for BDNF, in Parvalbumin-positive (PV⁺) interneurons has a pivotal role in cortical network changes. However, it is unknown if the activation of TrkB in PV⁺ interneurons is important for other plasticity-related behaviors, especially for learning and memory. Here, using mice with heterozygous conditional TrkB deletion in PV⁺ interneurons (PV-TrkB hCKO) in IntelliCage and fear erasure paradigms, we show that chronic treat

SUBMITTER: Jetsonen E 

PROVIDER: S-EPMC10209093 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature