Disentangling the roles of dopamine and noradrenaline in the exploration-exploitation tradeoff during human decision-making.

ABSTRACT: Balancing the exploration of new options and the exploitation of known options is a fundamental challenge in decision-making, yet the mechanisms involved in this balance are not fully understood. Here, we aimed to elucidate the distinct roles of dopamine and noradrenaline in the exploration-exploitation tradeoff during human choice. To this end, we used a double-blind, placebo-controlled design in which participants received either a placebo, 400 mg of the D2/D3 receptor antagonist amisulpride, or 40 mg of the β-adrenergic receptor antagonist propranolol before they completed a virtual patch-foraging task probing exploration and exploitation. We systematically varied the rewards associated with choice options, the rate by which rewards decreased over time, and the opportunity costs it took

SUBMITTER: Cremer A 

PROVIDER: S-EPMC10209107 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature