Wistar rats choose alcohol over social interaction in a discrete-choice model.

ABSTRACT: Animal models of substance use disorders have been criticized for their limited translation. One important factor behind seeking and taking that has so far been largely overlooked is the availability of alternative non-drug rewards. We recently reported that only about 15% of outbred Wistar rats will choose alcohol over a sweet solution of saccharin. It was also shown using a novel operant model of choice of drugs over social rewards that social interaction consistently attenuates self-administration and incubation of craving for stimulants and opioids. Whether this is also true for alcohol and choice of alcohol over a sweet reward translates to social rewards is currently unknown. We therefore evaluated choice between alcohol and a social reward in different experimental settings in both

SUBMITTER: Augier G 

PROVIDER: S-EPMC10209174 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature