Radiomics analysis of bone marrow biopsy locations in [¹⁸F]FDG PET/CT images for measurable residual disease assessment in multiple myeloma.

ABSTRACT: The combination of visual assessment of whole body [¹⁸F]FDG PET images and evaluation of bone marrow samples by Multiparameter Flow Cytometry (MFC) or Next-Generation Sequencing (NGS) is currently the most common clinical practice for the detection of Measurable Residual Disease (MRD) in Multiple Myeloma (MM) patients. In this study, radiomic features extracted from the bone marrow biopsy locations are analyzed and compared to those extracted from the whole bone marrow in order to study the representativeness of these biopsy locations in the image-based MRD assessment. Whole body [¹⁸F]FDG PET of 39 patients with newly diagnosed MM were included in the database, and visually evaluated by experts in nuclear medicine. A methodology for the segmentation of biopsy sites fr

SUBMITTER: Milara E 

PROVIDER: S-EPMC10209284 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature