Enhancement of mesenchymal stem cells' chondrogenic potential by type II collagen-based bioscaffolds.

ABSTRACT:

Background

Osteoarthritis (OA) is a common degenerative chronic disease accounting for physical pain, tissue stiffness and mobility restriction. Current therapeutic approaches fail to prevent the progression of the disease considering the limited knowledge on OA pathobiology. During OA progression, the extracellular matrix (ECM) of the cartilage is aberrantly remodeled by chondrocytes. Chondrocytes, being the main cell population of the cartilage, participate in cartilage regeneration process. To this end, modern tissue engineering strategies involve the recruitment of mesenchymal stem cells (MSCs) due to their regenerative capacity as to promote chondrocyte self-regeneration.

Methods and results

In the present study, we evaluated the role of type II collagen, as the main ma

SUBMITTER: Piperigkou Z 

PROVIDER: S-EPMC10209287 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature