"Neural Noise" in Auditory Responses in Young Autistic and Neurotypical Children.

ABSTRACT: Elevated "neural noise" has been advanced as an explanation of autism and autistic sensory experiences. However, functional neuroimaging measures of neural noise may be vulnerable to contamination by recording noise. This study explored variability of electrophysiological responses to tones of different intensities in 127 autistic and 79 typically-developing children aged 2-5 years old. A rigorous data processing pipeline, including advanced visualizations of different signal sources that were maximally independent across different time lags, was used to identify and eliminate putative recording noise. Inter-trial variability was measured using median absolute deviations (MADs) of EEG amplitudes across trials and inter-trial phase coherence (ITPC). ITPC was elevated in autism in the 50 and

SUBMITTER: Dwyer P 

PROVIDER: S-EPMC10209352 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature