Antibody-Functionalized Copper Oxide Nanoparticles with Targeted Antibacterial Activity.

ABSTRACT: Copper oxide nanoparticles (CuO-NPs) were functionalized with specific antibodies to target their antibacterial activity against Gram-positive or Gram-negative bacteria. The CuO-NPs were covalently functionalized to cover their surface with specific antibodies. The differently prepared CuO-NPs were characterized by X-ray diffraction, transmission electron microscopy and dynamic light scattering. The antibacterial activities of the unmodified CuO-NPs and the antibody-functionalized nanoparticles (CuO-NP-AbGram^- and CuO-NP-AbGram⁺ ) were determined for both Gram-negative Escherichia coli and Gram-positive Bacillus subtilis bacteria. The antibody-functionalized NPs showed a differential increase of their antibacterial activity according to the specific antibody. The CuO-

SUBMITTER: Ontiveros-Robles JA 

PROVIDER: S-EPMC10209517 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature