Impact of (intestinal) LAL deficiency on lipid metabolism and macrophage infiltration.

ABSTRACT:

Objective

To date, the only enzyme known to be responsible for the hydrolysis of cholesteryl esters and triacylglycerols in the lysosome at acidic pH is lysosomal acid lipase (LAL). Lipid malabsorption in the small intestine (SI), accompanied by macrophage infiltration, is one of the most common pathological features of LAL deficiency. However, the exact role of LAL in intestinal lipid metabolism is still unknown.

Methods

We collected three parts of the SI (duodenum, jejunum, ileum) from mice with a global (LAL KO) or intestine-specific deletion of LAL (iLAL KO) and corresponding controls.

Results

We observed infiltration of lipid-associated macrophages into the lamina propria, where neutral lipids accumulate massively in the SI of LAL KO mice. In addition, LAL KO mic

SUBMITTER: Bianco V 

PROVIDER: S-EPMC10209539 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature