Multi-omic assessment shows dysregulation of pulmonary and systemic immunity to e-cigarette exposure.

ABSTRACT: Electronic cigarette (Ecig) use has become more common, gaining increasing acceptance as a safer alternative to tobacco smoking. However, the 2019 outbreak of Ecig and Vaping-Associated Lung Injury (EVALI) alerted the community to the potential for incorporation of deleterious ingredients such as vitamin E acetate into products without adequate safety testing. Understanding Ecig induced molecular changes in the lung and systemically can provide a path to safety assessment and protect consumers from unsafe formulations. While vitamin E acetate has been largely removed from commercial and illicit products, many Ecig products contain additives that remain largely uncharacterized. In this study, we determined the lung-specific effects as well as systemic immune effects in response to exposure

SUBMITTER: Scieszka DP 

PROVIDER: S-EPMC10209577 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature