Rate of Advancement of Detection Limits in Mass Spectrometry: Is there a Moore’s Law of Mass Spec?

ABSTRACT: Mass spectrometry is a well-established analytical technique for studying the masses of atoms, molecules, or fragments of molecules. One of the key metrics of mass spectrometers is the limit of detection e.g., the minimum amount of signal from an analyte that can be reliably distinguished from noise. Detection limits have improved greatly over the last 30–40 years to the point that nanogram per litre and even picogram per litre detections are commonly reported. There is however, a difference between detection limits obtained with a single, pure compound in a pure solvent and those obtained from real life samples/matrixes. Determining a practical detection limit for mass spectrometry is difficult because it depends on multiple factors, such as the compound under test, the matrix, data proce

SUBMITTER: Beattie M 

PROVIDER: S-EPMC10209656 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature