Accelerating towards P. vivax elimination with a novel serological test-and-treat strategy: a modelling case study in Brazil.

ABSTRACT:

Background

Plasmodium vivax malaria is challenging to control and eliminate. Treatment with radical cure drugs fails to target the hidden asymptomatic and hypnozoite reservoirs in populations. PvSeroTAT, a novel serological test-and-treat intervention using a serological diagnostic to screen hypnozoite carriers for radical cure eligibility and treatment, could accelerate P. vivax elimination.

Methods

Using a previously developed mathematical model of P. vivax transmission adapted to the Brazilian context as a case study for implementation, we evaluate the public health impact of various deployment strategies of PvSeroTAT as a mass campaign. We compare relative reductions in prevalence, cases averted, glucose-6-phosphate dehydrogenase (G6PD)

SUBMITTER: Nekkab N 

PROVIDER: S-EPMC10209700 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature