Glial suppression and post-traumatic stress disorder: A cross-sectional study of 1,520 world trade center responders.

ABSTRACT:

Background

Chronically re-experiencing the memory of a traumatic event might cause a glial response. This study examined whether glial activation would be associated with PTSD in a study of responders present after the 9/11 World Trade Center attacks without comorbid cerebrovascular disease.

Methods

Plasma was retrieved from 1,520 WTC responders and stored for a cross-sectional sample of responders of varying levels of exposure and PTSD. Plasma levels (pg/ml) of glial fibrillary acidic protein (GFAP) were assayed. Because stroke and other cerebrovascular diseases cause distributional shifts in GFAP levels, multivariable-adjusted finite mixture models analyzed GFAP distributions in responders with and without possible cerebrovascular disease.

Results

Responders were ag

SUBMITTER: Natale G 

PROVIDER: S-EPMC10209702 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature