Gait and balance in apolipoprotein Ɛ4 allele carriers in older adults and Parkinson's disease.

ABSTRACT:

Background

Gait and balance impairments are among the most troublesome and heterogeneous in Parkinson's disease (PD). This heterogeneity may, in part, reflect genetic variation. The apolipoprotein E (APOE) gene has three major allelic variants (ε2, ε3 and ε4). Previous work has demonstrated that older adult (OA) APOE ε4 carriers demonstrate gait deficits. This study compared gait and balance measures between APOE ε4 carriers and non-carriers in both OA and PD.

Methods

334 people with PD (81 APOE ε4 carriers and 253 non-carriers) and 144 OA (41 carriers and 103 non-carriers) were recruited. Gait and balance were assessed using body-worn inertial sensors. Two-way analyses of covariance (ANCOVA) compared gait and balance characteristics between AP

SUBMITTER: Morris R 

PROVIDER: S-EPMC10209874 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature